Pandorum·1 month ago
1 month ago
Associate Research Scientist - Organoid
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What you'll do
- Develop, optimize, and characterize robust human 3D organoid/spheroid models, including multicellular co-culture systems, for disease modelling and therapeutic efficacy applications spanning metabolic, fibrotic, inflammatory, and toxicological indications.
- Perform advanced mammalian cell culture, including primary cells, stem cells, and co-culture systems, with multicellular organoid assembly experience preferred, maintaining strong experimental rigor and reproducibility throughout.
- Design and standardize reproducible protocols for 3D organoid model generation, maintenance, maturation, differentiation, cryopreservation, recovery, and quality control, demonstrating strong command of tissue engineering principles.
- Design, execute, and optimize functional assays evaluating viability, metabolism, DMPK studies, tissue-specific function, biomarker expression, and therapeutic response.
- Working proficiency in techniques such as RT-qPCR, ELISA, Western blotting, ICC, IF, and flow cytometry, along with histology pipelines for tissue characterization, is required.
- Expertise in fluorescence and confocal microscopy with quantitative image analysis to characterize structural and functional readouts of 3D organoid models; exposure to high-content imaging and automated image analysis is a plus.
- Design experiments independently, analyze complex biological datasets, and interpret results, with solid grounding in experimental design, statistical analysis, and scientific data interpretation. Ability to prepare publication-quality figures, technical reports, and presentations is essential.
- Contribute to mechanism-of-action studies by integrating molecular, functional, and phenotypic datasets, and develop, optimize, and validate novel assays and workflows that enhance the reproducibility, throughput, and translational relevance of organoid-based models; experience in biomarker identification, selection, and validation is preferred
- Maintain comprehensive scientific documentation, including lab notebooks, SOPs, protocols, and validation reports, in compliance with internal quality systems.
- Support scientific publications, IP generation, grant proposals, and external collaborations through data generation, analysis, and scientific writing; publication or patent experience is a plus.
- Collaborate effectively across biology, bioengineering, translational research, computational biology, and process development to drive project objectives, with strong communication, presentation, and interpersonal skills to thrive in a fast-paced, multidisciplinary research environment.
What they're looking for
- PhD in a relevant discipline with 0-2 years of postdoctoral and/or industry research experience in Liver and Lung Organoids
- Master’s degree with 4+ years relevant research experience in Cell Biology, Molecular Biology, Biotechnology, Biochemistry, Regenerative Medicine, Tissue Engineering, Biomedical Sciences, or a related discipline
Nice to have
- Multicellular organoid assembly experience preferred
- Exposure to high-content imaging and automated image analysis is a plus
- Experience in biomarker identification, selection, and validation is preferred
- Publication or patent experience is a plus
Summarised by NextRaise from the employer’s description, which follows in full below.
Full description from employer
Key Responsibilities
- Develop, optimize, and characterize robust human 3D organoid/spheroid models, including multicellular co-culture systems, for disease modelling and therapeutic efficacy applications spanning metabolic, fibrotic, inflammatory, and toxicological indications.
- Perform advanced mammalian cell culture, including primary cells, stem cells, and co-culture systems, with multicellular organoid assembly experience preferred, maintaining strong experimental rigor and reproducibility throughout.
- Design and standardize reproducible protocols for 3D organoid model generation, maintenance, maturation, differentiation, cryopreservation, recovery, and quality control, demonstrating strong command of tissue engineering principles.
- Design, execute, and optimize functional assays evaluating viability, metabolism, DMPK studies, tissue-specific function, biomarker expression, and therapeutic response.
- Working proficiency in techniques such as RT-qPCR, ELISA, Western blotting, ICC, IF, and flow cytometry, along with histology pipelines for tissue characterization, is required.
- Expertise in fluorescence and confocal microscopy with quantitative image analysis to characterize structural and functional readouts of 3D organoid models; exposure to high-content imaging and automated image analysis is a plus.
- Design experiments independently, analyze complex biological datasets, and interpret results, with solid grounding in experimental design, statistical analysis, and scientific data interpretation. Ability to prepare publication-quality figures, technical reports, and presentations is essential.
- Contribute to mechanism-of-action studies by integrating molecular, functional, and phenotypic datasets, and develop, optimize, and validate novel assays and workflows that enhance the reproducibility, throughput, and translational relevance of organoid-based models; experience in biomarker identification, selection, and validation is preferred
- Maintain comprehensive scientific documentation, including lab notebooks, SOPs, protocols, and validation reports, in compliance with internal quality systems.
- Support scientific publications, IP generation, grant proposals, and external collaborations through data generation, analysis, and scientific writing; publication or patent experience is a plus.
- Collaborate effectively across biology, bioengineering, translational research, computational biology, and process development to drive project objectives, with strong communication, presentation, and interpersonal skills to thrive in a fast-paced, multidisciplinary research environment.
Qualifications and Experience
PhD in a relevant discipline with 0-2 years of postdoctoral and/or industry research experience in Liver and Lung Organoids; OR
Master’s degree with 4+ years relevant research experience in Cell Biology, Molecular Biology, Biotechnology, Biochemistry, Regenerative Medicine, Tissue Engineering, Biomedical Sciences, or a related discipline
Company
Pandorum
Bengaluru, India
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